The story follows the manhunt for the Zodiac Killer, a serial killer who terrorized the San Francisco Bay Area during the late 1960s and early 1970s, taunting police with letters, bloodstained clothing, and ciphers mailed to newspapers.

Cast: Jake Gyllenhaal, Mark Ruffalo, Anthony Edwards, Robert Downey Jr., Chloë Sevigny, Elias Koteas